If private property, freedom of business, and market price are accepted as a significant part of the basic principles of economics, at least among classical economists, Iran's economy does not have a suitable level in the indicators related to the above principles. In the current sensitive situation, to improve the economic situation of the country, it is necessary to deepen and clarify more in dealing with the nature of economic problems and to re-examine the basics. In this regard, this article intends to examine the theory of natural rights with an economic approach and by emphasizing the opinions of three prominent theorists, with an analytical-comparative method. The theory of natural rights as the essential and fundamental right of individuals has an ancient lineage, but in most cases, it has been considered from the perspective of law and politics. Examining this theory with an economic approach is, on the one hand, an attempt to answer whether the relationship between the principles to what extent is the science of economics and the theory of natural law. On the other hand, it specifies the degree of difference and affinity of the economic thought of the mentioned theorists. Therefore, the conclusion of this article, based on the thoughts of the three theorists mentioned the importance of empirical observations and giving legitimacy to the reason for abstract conclusions from these observations, as well as considering the way of discovering natural rights as the fruit of the participation of conscious creatures in God's law, There has been a meaningful connection between the principles of economics, which are derived from human nature in a rational and experimental process, and the natural right of people in society, so that THOMAS Aquinas and John Locke consider private property to be the natural right of people, and unlike THOMAS Hobbes, in their opinion, preserving and Protecting the said right requires that the power of the government is limited in limiting the ownership of the members of the society. Also, THOMAS Aquinas and THOMAS Hobbes consider the satisfaction of the exchange parties as the basis for determining the just price (market price) and it is based on this that the determination of the price of goods in a voluntary exchange free from coercion and fraud can be part of the natural right of humans in Aquinas's view. He considered the process of forming the economic relationship of people in a free business environment.